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Key Takeaway: Check your DXA muscle index (ALMI) against the EWGSOP2 sarcopenia cut-off and the NHANES quintiles a 2025 mortality study used. For men over 40.

Man in his mid-50s performing a deadlift in a bare concrete gym, forearms and grip visible, shot in high-contrast black and white on Kodak Tri-X 400 with a Leica M6

A 2025 study in Scientific Reports followed 21,938 US adults aged 20 to 85 from the National Health and Nutrition Examination Survey (NHANES) for a median of 10.9 years. Each had a DXA scan that measured the muscle in their arms and legs. Men in the top fifth for this appendicular muscle index had an all-cause mortality hazard ratio of 0.54 (95% CI 0.41 to 0.72) compared with men in the bottom fifth, after adjustment for age, BMI, diabetes, heart attack, stroke, cancer and social factors. The European sarcopenia guideline (EWGSOP2) sets low muscle quantity in men at an index below 7.0 kg/m². The calculator below checks your DXA number against both.

Key Takeaways

  • In NHANES, men in the top fifth of appendicular muscle index had an adjusted all-cause mortality HR of 0.54 vs the bottom fifth (Cheng et al., 2025)
  • The lowest risk was in the fourth fifth (8.88 to 9.66 kg/m²; HR 0.44), not the top fifth
  • EWGSOP2 sets low muscle quantity in men at an ALMI below 7.0 kg/m² by DXA
  • Under EWGSOP2, sarcopenia starts with low strength; low muscle quantity confirms it
  • The weighted median ALMI for men in the study was 8.6 kg/m²

Research Calculator · EWGSOP2 2019 + NHANES (Cheng 2025)

Sarcopenia Risk Calculator (ALMI)

Enter the appendicular lean mass index from your DXA scan. The calculator checks it against the EWGSOP2 cut-off for men (7.0 kg/m²) and places it in the five groups a 2025 NHANES study of 21,938 US adults used to compare mortality.

Divide the lean mass of your arms and legs (kg) by your height in metres squared. Some reports call it ALMI, ASMI or SMI. The cut-offs here come from DXA; bioimpedance devices give different values.

Sources & citations

Cheng Y, Li T, Huang G, et al. "Low appendicular skeletal muscle mass is associated with the risk of mortality among adults in the United States." Scientific Reports. 2025;15(1):9908. DOI: 10.1038/s41598-025-94357-8. Cruz-Jentoft AJ, et al. "Sarcopenia: revised European consensus on definition and diagnosis." Age Ageing. 2019;48(1):16-31. DOI: 10.1093/ageing/afy169.

In this article: What your result means · Why ALMI predicts mortality · The research · How to measure · How to improve · FAQ

What Your Result Means

The calculator places your DXA ALMI in one of the five groups Cheng and colleagues used for men, and flags any value under the EWGSOP2 cut-off.

Men's quintileALMI (kg/m²)All-cause mortality HR vs Q1 (95% CI)
Q1 (lowest)below 7.601 (reference)
Q27.60 to 8.280.72 (0.61 to 0.84)
Q38.28 to 8.880.59 (0.47 to 0.74)
Q48.88 to 9.660.44 (0.34 to 0.56)
Q5 (highest)above 9.660.54 (0.41 to 0.72)

From Cheng et al., Sci Rep 2025, Methods and Table 2, fully adjusted model.

Fourth or Fifth Quintile: Above 8.88 kg/m²

Men here had the lowest mortality in the study. The authors describe an L-shaped curve for men: risk falls fast as ALMI rises and levels off around 10 kg/m². More muscle beyond that point showed no extra benefit. Your aim is to hold what you have. Rescan once a year on the same machine.

Second or Third Quintile: 7.60 to 8.88 kg/m²

This is the middle of the male range; the weighted median in the study was 8.6 kg/m². Men in these groups had lower mortality than the bottom fifth (HR 0.72 and 0.59). Strength training is the tool for moving up.

Bottom Quintile, Above the Cut-Off: 7.0 to 7.60 kg/m²

Men in the bottom fifth had the highest mortality in the study and served as the reference group. You are above the EWGSOP2 cut-off, so this is not low muscle quantity under the guideline. Track the trend between scans, and talk to your doctor if you are losing muscle without a reason you know of.

Below the EWGSOP2 Cut-Off: Under 7.0 kg/m²

EWGSOP2 uses an appendicular muscle index below 7.0 kg/m² in men as its cut-off for low muscle quantity. The guideline starts with strength: low grip strength flags probable sarcopenia, and low muscle quantity confirms it. Check your grip with the Grip Strength Calculator and bring both results to your doctor.

Why ALMI Predicts Mortality

ALMI measures the muscle in your arms and legs, scaled to your height. Researchers use it as a stand-in for overall muscle because DXA can measure the limbs separately from the trunk and organs.

The link is not the same for every cause of death. In the Cheng study, higher ALMI was associated with lower all-cause and cancer mortality. The association with heart disease mortality was not significant.

It differs by sex. For men, the trend across quintiles was significant. For women, it was not (P = 0.076), and the curve was U-shaped.

Muscle travels with other things. People with more muscle in the study were younger on average, and the authors adjusted for age, BMI and disease history. Observational data cannot rule out that something else, such as overall health or activity, explains part of the link.

The study does not show that building muscle lowers your mortality risk. It shows that, in a large US sample, men with more limb muscle died less often over about 11 years.

The Research Behind the Calculator

Cheng et al., Scientific Reports 2025 (NHANES)

Cheng and colleagues pooled NHANES cycles from 1999 to 2006 and 2011 to 2018, linked to the national death records up to 2018. Of 21,938 adults aged 20 to 85, 11,025 were men; the mean age was 41. During a median follow-up of 10.9 years, 1,632 men and 1,253 women died. The researchers split each sex into fifths by DXA appendicular muscle index and compared mortality with Cox models.

For men, the adjusted hazard ratios against the bottom fifth were 0.72, 0.59, 0.44 and 0.54 for the second to fifth quintiles. Each 20-percentile step up in ALMI was associated with 18% lower all-cause mortality in men (HR 0.82, 95% CI 0.77 to 0.88).

EWGSOP2 Guidelines

The European Working Group on Sarcopenia in Older People revised its definition in 2019. EWGSOP2 puts low muscle strength first (grip below 27 kg in men) as the sign of probable sarcopenia, confirms sarcopenia with low muscle quantity or quality (appendicular muscle index below 7.0 kg/m² in men), and calls it severe when physical performance is also low.

What These Studies Do Not Prove

The NHANES analysis is observational. It adjusts for known confounders but cannot prove cause and effect. A single DXA number does not predict your own outcome. The study measured US adults with one DXA protocol; another machine or method can give a different number, so compare like with like.

How to Measure Your ALMI

DXA Scan

DXA (dual-energy X-ray absorptiometry) is the method the NHANES study and the EWGSOP2 cut-off use. A whole-body scan reports lean mass for each arm and leg. Add the four, then divide by your height in metres squared to get ALMI. Ask your doctor whether a body composition scan makes sense for you.

Bioimpedance Devices

Bioimpedance (BIA) devices, from clinic machines to bathroom scales, estimate muscle from electrical resistance. They do not measure the same thing as DXA, and their numbers do not map onto the DXA cut-offs in this calculator. Use them to watch your own trend on the same device, not to compare with the tables above.

How to Build and Preserve Muscle Mass

Resistance Training

Mechanical load on muscle is the signal that builds and keeps it. Train every major muscle group, with compound movements such as squats, deadlifts, bench press, rows and overhead press. See 10 Best Compound Exercises for Men Over 45 for a progression guide.

Progressive overload, adding weight or reps over months, keeps the signal going. Doing the same weight for the same reps for years maintains, but rarely builds.

Protein

A 2018 meta-analysis of 49 trials (1,863 people) found that protein supplements added to the muscle gained from resistance training, with no further gain in fat-free mass above a total intake of about 1.6 g per kg of body weight per day. The benefit shrank with age. For targets and food sources, see How Much Protein Does a 45-Year-Old Man Need?

Creatine

Creatine monohydrate is the most studied supplement for muscle and strength. For what the trials in older adults found, see Creatine for Men Over 40: Benefits, Risks, and Dosage.

Recovery

Sleep and rest between sessions support training. For a full recovery framework, see 12 Muscle Recovery Tips Every Man Over 40 Should Know.

Related Longevity Tests

ALMI is one of several physical measurements studied for their link to mortality. Others on PrimeVital:

Talk to your doctor before starting any new exercise program. The results from this calculator are for education only and are not medical advice or a diagnosis.


FAQ

What is ALMI and how is it different from BMI?

ALMI (appendicular lean mass index) is the lean mass of your arms and legs divided by your height squared. BMI divides total body weight by height squared and cannot tell fat from muscle. Two men with the same BMI can have very different ALMI values. BMI does not detect low muscle; ALMI from DXA does.

Where can I get a DXA scan?

Imaging centres, some hospitals and some sports clinics offer whole-body DXA. Your doctor can tell you whether a scan makes sense for you and where to get one. Ask for a body composition scan with regional lean mass, so the report shows arms and legs separately.

Is 7.0 kg/m² the threshold for every man?

It is the EWGSOP2 cut-off for low muscle quantity in men measured by DXA. Other guidelines and other measurement methods use different cut-offs, so the number is not universal. Under EWGSOP2, low muscle quantity confirms sarcopenia only alongside low strength. Talk to your doctor about which definition applies to you.

What ALMI had the lowest mortality in men?

In the 2025 NHANES study, men in the fourth fifth (8.88 to 9.66 kg/m²) had the lowest adjusted risk, HR 0.44 compared with the bottom fifth. The top fifth had HR 0.54. The authors describe an L-shaped curve that levels off around 10 kg/m², with no extra benefit beyond it.

Can I use a smart scale or InBody instead of DXA?

Bioimpedance devices estimate muscle and can track your own trend on the same device. Their numbers do not match DXA, so the 7.0 kg/m² cut-off and the NHANES quintiles in this calculator do not apply to them. Enter only a DXA value here.

Does building muscle lower mortality?

No study behind this calculator tested that. The NHANES result is an association: men with more limb muscle died less often over about 11 years. Resistance training builds muscle and strength at any age, which is a good reason on its own. Talk to your doctor before you start if you have a health condition.

How often should I retest ALMI?

Muscle changes slowly, so frequent scans add noise. Once a year is enough to see a trend for most men. If you are training to build muscle from a low starting point, ask your doctor about rescanning sooner. Use the same machine each time, ideally at the same time of day.

References

The sources this article links to, in the order they appear.

  1. 2025 study in Scientific Reports
  2. European sarcopenia guideline (EWGSOP2)
  3. Cheng et al., Sci Rep 2025
  4. 2018 meta-analysis
  5. PURE study
  6. 2023 JACC meta-analysis
  7. EJPC 2014

Keep reading

More from Fitness for men over 40.

Medical Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before starting any new exercise, nutrition, or supplement program. Written and reviewed by The PrimeVital Desk.